105 (Phospho)proteomics biomarkers for sunitinib response in RCC LIST OF ABBREVIATIONS (cc)RCC (Clear cell) Renal cell carcinoma DMEM Dulbecco’s Modified Eagle Medium EGFR Epidermal Growth Factor Receptor FBS Fetal bovine serum FC Fold-change FDR False discovery rate FGF Fibroblast Growth Factor GSEA Gene Set Enrichment Analysis ICI Immune checkpoint inhibitors INKA Integrative Inferred Kinase Activity IP Immunoprecipitation KIT Stem cell factor receptor LC-MS/MS liquid chromatography coupled to tandem mass spectrometry MAPK Mitogen-activated Protein Kinase mRCC metastatic renal cell carcinoma OS Overall survival PBS Phosphate-buffered saline PDGFR Platelet-Derived Growth Factor Receptor PFS Progression-free survival P-proteomics Phosphoproteomics PTM Post-translational modification PTM-SEA Post-translational modifications signature enrichment analysis pTyr Phosphotyrosine RES Resistant SENS Sensitive TKI Tyrosine kinase inhibitor VEGFR Vascular Endothelial Growth Factor Receptor 4
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