118 CHAPTER 4 b: phosphosites upregulated in sensitive patients (continued) Phosphosite p-value FC Role of corresponding protein in RCC CDK2_S90 n/a n/a CDK2 kinase activity is required for proper cell cycle progression and is involved in oncogenesis of multiple tumor types, among which RCC100. NSFL1C_Y167 n/a n/a No literature describing a role in RCC. FLNA_Y346 n/a n/a FLNA expression is correlated with lymph node metastases, clinical stage, histological grade and poor overall survival in RCC, suggesting that it plays a role as tumor suppressor in RCC101. MTMR10_Y708 n/a n/a No literature describing a role in RCC. AKR1A1_Y50 n/a n/a No literature describing a role in RCC. BCAR1_Y304 n/a n/a No literature describing a role in RCC. GRASP_Y94 n/a n/a No literature describing a role in RCC. TUBA1B_Y357 n/a n/a No literature describing a role in RCC. TNS2_Y581 n/a n/a No literature describing a role in RCC. ARAP1_Y747 n/a n/a No literature describing a role in RCC. SHANK2_Y321 n/a n/a No literature describing a role in RCC. GSTA1_Y132 n/a n/a The exosomal shuttle RNA GSTA1 was significantly decreased in the urinary extracellular vesicles of patients with ccRCC compared to healthy subjects102. PYGL_Y170 n/a n/a No literature describing a role in RCC. NIPSNAP1_ Y148 n/a n/a No literature describing a role in RCC. SDHA_Y523 n/a n/a SDHA is one of the four subunits of SDH, a well-recognized tumor suppressor gene involved in RCC carcinogenesis by SDH deficiency-driven HIF-α stabilization and activation, leading to increased VEGFmediated angiogenesis. SDH deficient RCC form a distinct clinicopathological subtype of RCC103. FBP2_Y216 n/a n/a No literature describing a role in RCC. HINT2_Y146 n/a n/a No literature describing a role in RCC.
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