120 CHAPTER 4 b: phosphosites upregulated in sensitive patients (continued) Phosphosite p-value FC Role of corresponding protein in RCC Differentially upregulated (not unique) HSPB1_S15 0.001 -6.9 HSPB1 (=HSP27) is significantly overexpressed in RCC compared to normal kidney tissue114 and when activated, attributes to promotion of cancer development and metastatic potential. Inactivation of the pathway may attenuate the invasion and migration capabilities in RCC115. PPA2_Y241 0.004 -4.8 No literature describing a role in RCC. CAVIN1_Y308 0.005 -8.6 CAVIN1/PTRF expression in ccRCC is regulated by SHC1 through the EGFR pathway. Abnormal PTRF, which is detected in exosomes from urine, could be a potential marker for ccRCC diagnosis and treatment116. PTK2_Y879 0.007 -3.1 Focal Adhesion Kinase (FAK/PTK2) is constitutively expressed in RCC and has a contributing role in proliferation, migration and invasion117. MYL6_Y86 0.009 -15.5 No literature describing a role in RCC. NAXD_Y85 0.012 -4.5 No literature describing a role in RCC. MAPK1_Y187 0.015 -3.8 Constitutive activation of the MAPK signaling cascade plays a crucial role in tumorigenesis and metastasis in RCC118. MAPK1 (=ERK2) is significantly overexpressed in RCC compared to normal tissue119. GSK3A_Y279 0.023 -2.3 No literature describing a role in RCC. TNK2_Y859 0.027 -16.9 A mutation in the ACK1 (= TNK2) ubiquitin associated domain enhances oncogenic signaling through EGFR regulation in RCC cells120. LPP_Y295 0.028 -3.4 No literature describing a role in RCC. PXN_Y402 0.031 -30.6 The mRNA expression of paxillin (PXN) was upregulated in metastatic RCC cells compared to normal renal tissue. Paxillin upregulation may contribute to the pathogenicity and/or metastatic propensity of RCC and may have a role as potential marker of metastasis in RCC cells121. FGR_Y145 0.032 -13.4 FGR is one of the five highly expressed Src family kinases in ccRCC. A relation with survival or response to therapy has not been demonstrated122. GSK3A_S282 0.036 -2.2 No literature describing a role in RCC. RPS27_Y31 0.038 -11.0 No literature describing a role in RCC. MAPRE2_Y167 0.040 -5.3 No literature describing a role in RCC.
RkJQdWJsaXNoZXIy MTk4NDMw