121 (Phospho)proteomics biomarkers for sunitinib response in RCC b: phosphosites upregulated in sensitive patients (continued) Phosphosite p-value FC Role of corresponding protein in RCC MAPK1_Y187 0.041 -5.6 Constitutive activation of the MAPK signaling cascade plays a crucial role in tumorigenesis and metastasis in RCC118. MAPK1 (=ERK2) is significantly overexpressed in RCC compared to normal tissue119. MAPK1_T185 0.041 -5.6 Constitutive activation of the MAPK signaling cascade plays a crucial role in tumorigenesis and metastasis in RCC118. MAPK1 (=ERK2) is significantly overexpressed in RCC compared to normal tissue119. PAG1_Y317 0.042 -5.3 Overexpression of Csk-binding protein (= PAG1) is found in over 70% of RCC tissues and contributes to renal cell carcinogenesis123. PTPRK_Y871 0.042 -5.3 No literature describing a role in RCC. PGAM1_Y92 0.042 -3.6 PGAM1 is highly expressed in ccRCC and correlates with clinicopathological features, such as tumor size124. CD84_Y165 0.044 -5.4 No literature describing a role in RCC. 4
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