126 CHAPTER 4 Supplementary Figure 4. Ranking of most activated kinases per sample Ranking of the top 20 active kinases (Y-axis) in tumors from 16 sensitive and 7 resistant patients. Bar graphs depict kinase ranking based on combined INKA scores of kinase- and substrate-centric analysis of tyrosine phosphoproteomics24. X-axis represents the INKA score for each kinase. Differentially activated kinases between the two groups (Figure 1c) are highlighted with dark (EGFR, MAPK3) and light (INSR/ IGF1R) green coloring.
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