42 CHAPTER 2 Extended Data Figure 2. Case submissions and reasons for non-accrual. Overview of the first 642 case submissions (submitted between 1 September 2016 and 1 September 2018), as well as the reasons for not being enrolled in the study. Values are displayed as a percentage relative to these 642 case submissions, and as an absolute number per category. Cases that were erroneously submitted (owing to incomplete understanding of the study protocol and/or retraction of the submission by the treating physician) are not included in this overview (n = 58 cases).
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