43 The Drug Rediscovery Protocol Extended Data Figure 3. Baseline biopsies for biomarker analyses. Overview and success rate of WGS on pre-treatment tumour biopsies. The bottom panel displays the number of patients for whom WGS succeeded, and indicates whether the initial variant (on the basis of which the patient started the study treatment) was also present in the fresh baseline biopsy. Values are displayed as absolute numbers and percentages, relative to the 131 successfully sequenced biopsies. CPCT-02, the national WGS programme of the CPCT; HML, high mutational load (defined as ≥140 somatic missense variants across the tumour genome overall); WGS-MSI, microsatellite instability suspected on the basis of WGS results; ampl, amplification; mut, mutation; wt, wild type. 2
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