50 CHAPTER 2 Extended Data Table 4. Adverse events in the first 215 patients (continued) Adverse event Grade 3 Grade 4 Grade 5 Bacterial peritonitis 1 Baseline biopsy-related bleeding 1 Bile duct stenosis 2 Bilirubin ↑ 4 Bleeding 3 Blindness 1 Cauda equina syndrome 1 Cholangitis 1 Cholecystolithiasis 1 1 Delirium 1 Diarrhea 3 Duodenal Perforation 1 Dyspnea 8 2 Encephalopathy 1 1 Ejection fraction ↓ 1 Fatigue 4 Fever 2 Flu like symptoms 2 GGT ↑ 16 1 Gastro-enteritis 2 General malaise 1 Hepatic impairment 2 Hip Fracture 1 Hydronephrosis 2 Hypercalcemia 1 1 Hypertension 8 Hypoalbuminemia 1 Hyponatremia 3 Hypophosphatemia 1 Hypotension 1 Hypoxia 1 Infusion related reaction 1 LDH ↑ 1 Lymphocyte count↓ 2 Muscle weakness 1 Nausea 4
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