TABLE OF CONTENTS Chapter 1 General introduction 9 Chapter 2 The Drug Rediscovery protocol facilitates the expanded use of existing anticancer drugs 23 Chapter 3 Patients with Biallelic BRCA1/2 Inactivation Respond to Olaparib Treatment Across Histologic Tumor Types 55 Chapter 4 Candidate biomarkers for treatment benefit from sunitinib in patients with advanced renal cell carcinoma using mass spectrometry-based (phospho)proteomics 87 Chapter 5 Advancing wide implementation of precision oncology: A liquid nitrogen-free snap freezer preserves molecular profiles of biological samples 129 Chapter 6 Summarizing discussion and future perspectives 157 Chapter 7 Nederlandse samenvatting 177 Chapter 8 Appendices Dankwoord Curriculum vitae List of publications 187 188 195 196
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