82 CHAPTER 3 Previous Systemic Treatments (PST) Patient PST 1 Best response to PST 1 PST 2 Best response to PST 2 PST 3 Best response to PST 3 PST 4 Best response to PST 4 PST 5 Best response to PST 5 PST 6 Best response to PST 6 1 Cisplatinum + Gemcitabine PR 2 Gosereline NE Docetaxel SD Cabazitaxel PD Enzalutamide PD 3 5-Fluorouracil + epirubicin + cyclophosphamide n/a (adjuvant) Anastrozole SD Tamoxifen SD 4 Pazopanib SD Nivolumab PD Cabozantinib PD 5 Adriamycine + Cyclophosphamide + Docetaxel NE Carboplatinum + paclitaxel CR Methotrexate + Cytarabine Non-CR/ Non-PD Capecitabine PD 6 Gosereline NE Bicalutamide NE Docetaxel unknown Enzalutamide unknown 7 LHRH NE Docetaxel NE Abiraterone SD 8 Leuproreline + bicalutamide SD Docetaxel PD Radium-223 SD Abiraterone PD Carboplatinum + cabazitaxel SD 9 Bicalutamide NE Abiraterone + Apalutamide NE Degarelix NE Myeloid and plasmacytoid dendritic cell vaccination PD Enzalutamide PD 10 Gosereline PD Docetaxel PD Abiraterone PD Cabazitaxel + carboplatin SD 11 Bicalutamide PR Degarelix PD Docetaxel PR Enzalutamide PD Cabazitaxel Response 12 Carboplatinum + paclitaxel ND Carboplatinum + paclitaxel Non-CR/ non-PD Carboplatinum + paclitaxel PR Carboplatinum + liposomal doxorubicin Non-CR/ non-PD 13 Carboplatinum + gemcitabine PR
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