Chapter 5 106 Method Two librarians, one from the medical sciences and one from social sciences, assisted with the development of a search strategy and the selection of the appropriate databases. Our research included health research related to biomedical, nursing, and allied health and public health sciences. We performed multiple test runs to optimize the search strategy, before the first search in July 2019. A final search was performed in August 2020 to update the included publications. The protocol for this review can be found in supplement 1. Search Strategy We performed electronic searches in the following databases: PubMed, CINHAL, Embase, Cochrane Library, Web of Science, PsycInfo and Sociological Abstracts. Grey literature searches were not included. We searched for studies in the English language, published between 2000 and 2020. For the medical databases the following terms were employed: “Human-centred” OR “Human-centred” OR “User-centred” OR “User-centred” AND “Design OR approach” OR “Design thinking”. For the non-medical databases, the following search terms were added: “Health” OR “Medic” OR “Clinic”. The exact search algorithms per database can be found in supplement 2. Eligibility criteria We included health research studies that 1) applied human-centred design (HCD), usercentered design (UCD) or design thinking (DT), 2) focused on the development process of a health innovation and 3) provided a detailed description of the design process, which included: 4) the applied process steps and/or phases, 5) the applied design methods per process step and/or phase and 6) a description of the involved design team and end-users. We excluded studies if 1) the study did not focus on the design process and 2) the study did not provide a detailed description of the design process and the HCD/DT/UCD methods used in the study. No specific criteria were formulated related to the end-user population. We conceptualised a ´health innovation' as it is applied within the context of health research according to the World Health Organization concept of: “Health innovation identifies new or improved health policies, systems, products and technologies, and services and delivery methods that improve people’s health and wellbeing.” Screening and data extraction We downloaded relevant papers into the Endnote bibliographic software (Clarivate Analytics, Philadelphia, PA, USA) and removed the duplicates. We then uploaded the Endnote database with the remaining papers into Rayyan, a web application that supports the initial screening of publication titles and abstracts.[19] Two reviewers screened the
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