Human Centered Design in Health Research 109 5 Results In the following sections we will provide an overview of the literature search results and the study characteristics of the included studies. Subsequently, several aspects of studies are highlighted, including the applied design theories, guidelines, strategies, and design process steps. Furthermore, we evaluate the applied research and design methods and the role in which end-users were involved throughout the studies. Our literature search identified 7560 records. After removal of 4072 duplicates and exclusion on the basis of abstract (3097) and full text (309), 82 articles were included into the final analysis (figure 1). Interrater agreement on the inclusion and exclusion of the studies was 96%, with a Cohen’s Kappa of 0.81. Screening Included Eligibility Identification Records identified through database searching (n = 7560) Records screened by title and abstract after duplicates removed (n = 3488) Records excluded on the basis of title and abstract (n = 3097) Full-text articles assessed for eligibility (n = 391) Full-text articles excluded (n = 309) Studies included in qualitative synthesis (n = 82) Figure 1. PRISMA Flowchart of the screening process
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