114 Chapter 5 Figure 1. Flow-chart of the in- and exclusion separately for the tumor and stroke population. Lesion topography The lesion overlay images of both groups showed a wide distribution of lesions covering both hemispheres (Figure 2). Tumor lesions were most often located in the left hemisphere, with the highest frequency of lesions in the insula, operculum and superior temporal gyrus. In the right hemisphere the maximum overlap was located more posterior in the pre- and postcentral gyrus. Most stroke lesions were located within the territory of the right middle cerebral artery, with maximum overlap in the insula, putamen and operculum. In total 46.4% of the voxels were lesioned in at least one patient from both the tumor and stroke group. In 21.8% of the voxels both the tumor and the stroke group had at least 3 patients with a lesion. See Supplementary Table 4 for an overview of the average percentage of overlap for each atlas structure. For the tumor group, the thresholded lesion overlap map included 125 of the 150 atlas areas. For the stroke group, 98 areas had sufficient coverage. In these lesion maps, the median overlap per area was 12.8% and 4.8% for the tumor and stroke group respectively. The number of areas that had >5% of patients with overlapping lesions in both the tumor and the stroke populations, was limited to 38 out of the 124 atlas areas. Neurocognitive performance Fifty-five percent of the tumor patients and 71% of the stroke patients had a cognitive impairment on at least one cognitive task. Letter fluency (30%) and working memory
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