117 Etiology in Lesion-Symptom Mapping: Tumor vs. Stroke Multivariate lesion-symptom mapping results Direct recall verbal memory (Figure 4C) For tumor patients, SVR-LSM analysis indicated that worse performance on the RAVLT Direct Recall was most strongly associated with lesion in the left cingulum (8.0% of tested voxels in that area were significant). Significant voxels extended into the left hippocampus (60.7%), parahippocampal gyrus (24.8%), lingual gyrus (14.2%) and the fusiform gyrus (9.9%). Besides lesions in grey matter areas, lesions in the optic radiation (14.2%) and the inferior longitudinal fasciculus (ILF; 10.4%) were also significantly associated with worse performance. For the stroke group, lesions within the putamen were most strongly associated with worse performance (21.0% of tested voxels significant). Additionally, two leftsided white matter tracts, the inferior fronto-occipital fasciculus (IFOF; 13.7%) and the uncinate fasciculus (18.5%) were strongly associated with task performance. No directly overlapping significant voxels were found, but in both groups, lesions within the left IFOF were related to worse performance on the direct recall albeit with relatively less significant voxels in the tumor group (Figure 4C and Table 2 for a visual representation of all significant voxels and an overview of the percentage of tested voxels that were significant). 5
RkJQdWJsaXNoZXIy MTk4NDMw