121 Etiology in Lesion-Symptom Mapping: Tumor vs. Stroke Figure 5. SVR-LSM results for the letter fluency. The thresholded lesion overlap for this task is shown for both the tumor (A) and stroke group (B). The color bar indicates the number of patients with overlapping lesions. Voxels that were significantly associated with worse performance are shown for the tumor group (red) and the stroke group (blue) for the letter fluency (C). The colors indicate the p-value for each voxel. The green outline indicates the area within which both groups had a minimum lesion overlap of 3 patients. L = left, R= right. Stroke lesions within the left precentral gyrus (1.1%) were most associated with worse semantic fluency scores. In general, most brain areas did not overlap between the tumor and stroke LSM (Figure 6 and Table 2). Nevertheless, lesions in the left corticospinal tract and left precentral gyrus were associated with the task performance in both groups. Of note is that the percentage of significant voxels was lower in the stroke group, even though they contained peak significant values. 5
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