155 Hemodynamic Imaging in Brain Metastases: ASL vs. Hypercapnic BOLD RESULTS Participants In total, 20 patients were included in the APRICOT study in the given time period. Data of 14 of these participants was used in the current analysis and 6 patients were excluded due to various, mostly technical reasons (see Supplementary Table 1). The average age of the included patients was 65.1 years and four were female. On average patients had 5.4 brain metastases of which the average volume of the newly treated, non-resected brain metastases was 10.7 cc. Edema encompassed on average 23.93 cc of the brain. Two patients had previous resection of at least one brain matastasis and three patients had received previous brain radiotherapy. On average, 62.30 cc of the brain volume (5.7% of the total brain volume) showed steal phenomena as indicated by negative CVR values (Table 1). On average 13.4% (range: 0 – 43.6%) of the brain metastases volume and in 21.9% (range: 0 – 52.3%) of the edema volume showed steal. Table 1. Patient, treatment and volume information of the included subjects in this study. Patient number Age (years) Sex Primary tumor Number of BM BM volume (cc) Previous resection Previous RT Steal volume (cc) Edema volume (cc) APP001 56 F Gynecological 3 - Y Y 37.03 4.36 APP003 57 F Lung 7 4.32 N N 33.41 54.27 APP005 66 M Melanoma 18 0.87 N Y 57.81 12.46 APP006 81 M Melanoma 2 7.09 N N 40.40 17.10 APP007 62 F Lung 11 11.20 N N 74.75 19.46 APP008 72 M Kidney 1 17.56 N N 105.29 80.14 APP009 67 M Lung 8 1.17 N N 77.20 1.48 APP011 52 F Lung 8 50.64 N N 61.71 29.41 APP012 58 M Melanoma 9 0.67 N N 28.04 0.30 APP013 75 M Melanoma 2 9.44 N N 54.61 1.76 APP016 53 M Melanoma 2 0.13 N Y 43.71 - APP018 72 M Lung 2 1.75 N N 38.70 13.19 APP019 65 M Gastro-intestinal 1 23.85 N N 81.66 84.43 APP020 75 M Lung 1 - Y N 137.79 16.67 Abbreviations: BM, brain metastases; F, female; M, male; N, no; RT, radiotherapy; Y, yes. 6
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