16 Chapter 1 It is crucial to not only capture, but also comprehend the nature of post-radiotherapy changes on physiological imaging. Chapter 6 describes how imaging parameters derived from BOLD imaging and ASL measures were compared in patients with BMs before undergoing cranial radiotherapy. The study aimed to improve our understanding of the relationship between these two imaging techniques and their respective value in the BMs population. Building on the findings from the previous chapters, Chapter 7 provides preliminary evidence for the added value of several physiological MRI biomarkers in detecting changes after radiotherapy. Through a case-report the potential of these MRI biomarkers and their link to cognitive performance are described. A summary of the main findings and implications of all chapters within this doctoral thesis are discussed in Chapter 8 and 9, respectively.
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