Eva van Grinsven

195 Physiological MRI Biomarkers & Cognition after SRS for Brain Metastases REFERENCES 1. Rodgers ZB, Detre JA, Wehrli FW. MRI-based methods for quantification of the cerebral metabolic rate of oxygen. Journal of Cerebral Blood Flow and Metabolism 2016; 36: 1165–1185. 2. Fantini S, Sassaroli A, Tgavalekos KT, et al. Cerebral blood flow and autoregulation: current measurement techniques and prospects for noninvasive optical methods. Neurophotonics 2016; 3: 031411. 3. Murkin JM. Cerebral autoregulation: The role of CO2 in metabolic homeostasis. Semin Cardiothorac Vasc Anesth 2007; 11: 269–273. 4. Gerstenecker A, Nabors LB, Meneses K, et al. Cognition in patients with newly diagnosed brain metastasis: Profiles and implications. J Neurooncol 2014; 120: 179–185. 5. Achrol AS, Rennert RC, Anders C, et al. Brain metastases. Nat Rev Dis Primers; 5. Epub ahead of print 2019. DOI: 10.1038/s41572-018-0055-y. 6. Kienast Y, Von Baumgarten L, Fuhrmann M, et al. Real-time imaging reveals the single steps of brain metastasis formation. Nat Med 2010; 16: 116–122. 7. Fidler IJ, Yano S, Zhang RD, et al. The seed and soil hypothesis: Vascularisation and brain metastases. Lancet Oncology 2002; 3: 53–57. 8. Langley RR, Fidler IJ. The biology of brain metastasis. Clin Chem 2013; 59: 180– 189. 9. García-Gómez P, Valiente M. Vascular co-option in brain metastasis. Angiogenesis 2020; 23: 3–8. 10. Eichler AF, Chung E, Kodack DP, et al. The biology of brain metastases— translation to new therapies. Nat Rev Clin Oncol 2011; 8: 344–356. 11. El Kamar FG, Posner JB. Brain metastases. Semin Neurol 2004; 24: 347–362. 12. Lammertsma AA, Wise RJS, Cox TCS, et al. Measurement of blood flow, oxygen utilisation, oxygen extraction ratio, and fractional blood volume in human brain tumours and surrounding oedematous tissue. British Journal of Radiology 1985; 58: 725–734. 13. Fierstra J, van Niftrik C, Piccirelli M, et al. Diffuse gliomas exhibit whole brain impaired cerebrovascular reactivity. Magn Reson Imaging 2018; 45: 78–83. 14. Van Grinsven EE, Guichelaar; J, Philippens MEP, et al. Hemodynamic imaging parameters in brain metastases patients – Agreement between multi-delay ASL and hypercapnic BOLD. Journal of Cerebral Blood Flow and Metabolism; tbp. Epub ahead of print 2023. DOI: 10.1177/0271678X231196989. 15. Eichler AF, Loeffler JS. Multidisciplinary management of brain metastases. Oncologist 2007; 12: 884–898. 16. Brown WR, Blair RM, Moody DM, et al. Capillary loss precedes the cognitive impairment induced by fractionated whole-brain irradiation: A potential rat model of vascular dementia. J Neurol Sci 2007; 257: 67–71. 17. Park HJ, Griffin RJ, Hui S, et al. Radiation-induced vascular damage in tumors: Implications of vascular damage in ablative hypofractionated radiotherapy (SBRT and SRS). Radiat Res 2012; 177: 311–327. 18. Hou C, Gong G, Wang L, et al. The Study of Cerebral Blood Flow Variations during Brain Metastases Radiotherapy. Oncol Res Treat 2022; 45: 130–137. 19. Makale MT, McDonald CR, Hattangadi-Gluth JA, et al. Mechanisms of radiotherapy-associated cognitive disability in patients with brain tumours. Nat Rev Neurol 2017; 13: 52–64. 7

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