32 Chapter 2 increased from 19% at short-term to 35% at mid-term follow-up.39 Although group performance declined compared to both baseline and short-term follow-up when considering all 17 patients in the Onodera et al. cohort, improvements were observed in a subgroup of patients with a baseline BMs volume of <4.0 cc and in BMs patients surviving at least 12 months.25 A similar trend was reported by Saito et al., where the subgroup surviving at least 8 months (N = 19) had stable L&M performance over time.28 Thus, most patients further decreased in cognitive performance at mid-term follow-up, but in a subgroup of patients stable or improved cognitive performance was observed over time. Figure 1. PRISMA flow chart illustrating the systematic proves conducted to identify the article in this review. *14 original datasets
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