33 Cognitive Impact of SRS vs. WBRT: Systematic Review & Meta-analysis Table 2. Assessment of data quality for each included study listed from highest to lowest quality. + indicates 1 point awarded for that criterion, - indicates no points and +/- 0.5 points. Authors ≥20 patients ≥50% at first follow-up Corrected to norms Definition provided Adjusted for baseline Parallel tests Diversity NCA Overall quality WBRT Mehta et al., 2003 18,36–38 + + + + + - + 6 good Gondi et al., 2014 26,27,33 + + - + + + +/- 5.5 good Westover et al., 2020 41 + + - +/- + + + 5.5 good Saito et al., 2016 28 + + - + + + - 5 good Deng et al., 2017 35 + + - + + - + 5 good Zhu et al., 2018 40 + + - + + - + 5 good Zhan et al., 2018 39 + + - + + - 4 medium Onodera et al., 2014 25 + + + - - - + 4 medium Cheng et al., 2018 34 + + - - - - + 3 medium SRS Chang et al., 2007 29 - + + + + + + 6 good Brown et al., 2016 32 + + + + + - + 6 good Chang et al., 2009 31 + + - + + - + 5 good Habets et al., 2016 30,43 + - + + + - + 5 good Minniti et al., 2020 44 + + - + + + - 5 good Onodera et al., 2014 25 - + + - - - + 3 medium Kirkpatrick et al., 2015 24 + - - - - - +/- 1.5 low Abbreviations: NCA, neurocognitive assessment; RT, radiotherapy; SRS, stereotactic radiosurgery; WBRT, whole-brain radiotherapy. 2
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