39 Cognitive Impact of SRS vs. WBRT: Systematic Review & Meta-analysis Table 4: Main message of the studies categorized by type of radiotherapy. T = time point in months after radiotherapy. (continued) RT type Authors and year of publication Number of patients Time points NCF assessed in months after RT Definition of cognitive change Main message WBRT Deng et al., 2017 35 109 87-89* 61-64* 34-36* T0 T3 T5 T7 RCI T3: T5: T7: 22-38% of the patients deteriorated on overall cognitive performance, with greatest deterioration on learning and memory (22-37%), executive function (38%) and verbal fluency (32%) 40-55% of the patients deteriorated on at least one cognitive task, with greatest deterioration on learning and memory (5255%) and verbal fluency (53%) 47-61% of the patients deteriorated on at least one cognitive task, with greatest deterioration on executive function (61%) and verbal fluency (59%). Cheng et al., 2018 46 81 81 T0 T1 N.A. T1: Significantly decreased performance compared to T0 on global cognitive performance, attention, verbal fluency and event-based prospective memory. Stable performance on time-based prospective memory. Zhan et al., 2018 39 117 91 54 T0 T1 T2 T3 T4 T5 T6 RCI T3: T6: 19% of the patients deteriorated on learning and memory performance. 35% of the patients deteriorated on learning and memory performance. 2
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