42 Chapter 2 Table 4: Main message of the studies categorized by type of radiotherapy. T = time point in months after radiotherapy. (continued) RT type Authors and year of publication Number of patients Time points NCF assessed in months after RT Definition of cognitive change Main message SRS Chang et al., 2009 31 30 20 T0 T1 T2 T4 T6 T12 T15 T18 RCI T4: T6: Most cognitive decline on tests for learning and memory (20% of the patients on total recall). The mean posterior probability of decline was 24% for total recall, 6% for delayed recall end 0% for delayed recognition. Analyses were also performed for other cognitive tests, but might have been underpowered since the trial was stopped prematurely due to significant larger probability of decline on learning and memory (total recall) after 4 months in the SRS+WBRT versus the SRS alone group. The mean posterior probability of decline on total recall was 8%. Brown et al., 2016 32 111 63 10-12* 12-14* 9-10* T0 T1.5 T3 T6 T9 T12 ≥1 SD T3: T6: T9: 64% of the patients showed cognitive deterioration on ≥1 test compared to T=0. Most patients deteriorated on learning and memory (recognition) performance (23%) and information processing speed (19%) and least on verbal fluency (2%). In those patients surviving at least 12 months 50% deteriorated on at least 1 test compared to T=0. Most patients deteriorated on learning and memory (delayed recall) performance (33%) and none deteriorated on information processing speed. In those patients surviving at least 12 months 50% deteriorated on at least 1 test compared to T=0. Most patients deteriorated on learning and memory (delayed recall and discrimination index) performance (both 23%) and none on verbal fluency.
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