TABLE OF CONTENTS Chapter 1 General introduction and thesis outline 7 Part I: Neurocognitive functioning in patients with brain metastases Chapter 2 The impact of stereotactic or whole brain radiotherapy on neurocognitive functioning in adult patients with brain metastases – A systematic review & meta-analysis 25 Chapter 3 Different profiles of neurocognitive functioning in patients with brain metastases prior to brain radiotherapy 57 Chapter 4 Individualized trajectories in post-radiotherapy neurocognitive functioning of patients with brain metastases 79 Part II: Using imaging techniques to understand neurocognitive functioning Chapter 5 The impact of etiology in lesion-symptom mapping – A direct comparison between tumor and stroke 105 Chapter 6 Hemodynamic imaging parameters in brain metastases patients – Agreement between multi-delay ASL and hypercapnic BOLD 145 Chapter 7 Evaluating physiological MRI biomarkers and cognitive performance in patients with brain metastases after stereotactic radiosurgery - a preliminary analysis and case-report 171 Summary and Discussion Chapter 8 Summary 203 Chapter 9 Discussion 211 Chapter 10 Summary in Dutch (Nederlandstalige samenvatting) 235 Appendices List of publications 246 Educational portfolio 250 Dankwoord (Acknowledgements) 252 About the author 262
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