64 Chapter 3 Group performance for all other (sub)tests were not significantly different from the norm population (Supplementary Table 4). Figure 1. Stacked bar chart comparing pre-radiotherapy to the pre-cancer performance showing the percentage of patients reporting subjective improved, stable or declined performance for each cognitive domain ordered from most decline to least decline. Colors indicate extreme improvement (dark green), substantial improvement (green), subtle improvement (light green), stable performance (blue), subtle decline (light orange), substantial decline (orange) and extreme decline (dark orange). Values shown inside the bar are exact percentages of patients within that category. Note: stable performance (±5), subtle improvement or decline (±6-25), substantial improvement or decline (±26-50) and extreme improvement or decline (±>50). Abbreviations: EF, executive functioning. Individual-level: On the domain-level, severe deficits (-2.0SD) were most often observed for memory (35%), psychomotor speed (32%), and processing speed (28%). More subtle deficits (-1.5SD or -1.0SD) were found for attention (16% and 40%, respectively) and executive function (22% and 50%, respectively). Deficits in visuospatial functioning were least often found. On the task-level, cognitive impairments were detected across all tests. The percentages of patients with severe cognitive impairments (-2.0SD) were highest for HVLT-R (recognition: 32%, immediate 20%, delayed 16%), Grooved Pegboard (dominant: 26%, non-dominant 22%) and STROOP naming speed (19%). More subtle deficits (-1.5SD) were observed for the FEEST (29%) and the semantic fluency task (25%; Figure 2).
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