174 6 Chapter 6 Figure 4. Forest plot of comparison: 1 integrated disease management versus control, update, outcome: 1.13 Functional exercise capacity: 6MWD. 2.2.1 Subgroup analysis based on type of setting Of the studies reporting 6MWD at 12 months, two were conducted in primary care (Fernandez 2009; Gottlieb 2011), seven in secondary care (Engstrom 1999; Güell 2000; Jimenez-Reguera 2020; Kalter-Leibovici 2018; Kessler 2018; Littlejohns 1991; Wakabayashi 2011), and four in tertiary care (Ko 2016; Vasilopoulou 2017; Wang 2017; Zhang 2020). Tests for subgroup di erences showed no di erence in e ect based on setting (Chi² = 4.49, df = 2, P = 0.11). However, heterogeneity remained considerable for the secondary care subgroup (I² = 80%) and for the tertiary care subgroup (I² = 87%).
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