CHAPTER 1 14 Endometrioid Non-endometrioid Type 1 Type 2 Grade 1 EC Grade 2 EC Grade 3 EEC Serous Clear cell A. B. Low-grade High-grade Incidence 80% Incidence 20% Age 40-60 years Age 60-80 years Obesity High ER/PR expression Generally low ER/PR expression PTEN, PIK3CA or KRAS mutation (NSMP) C. Favorable prognosis Unfavorable prognosis Figure 1: A. Examples of type 1; grade 1 EC and grade 2 EC and examples of type 2; grade 3 EEC, serous and clear cell EC. B. The pie charts showing the distribution of the molecular subgroups within the different histology’s. C. The characteristics of type 1 EC and type 2 EC. Abbreviations: POLE, polymerase epsilon; TP53, tumor protein 53; MSI, microsatellite instable; NSMP, no specific molecular profile; ER, estrogen receptor; PR, progesterone receptor; PTEN, phosphatase and tensin homolog; PIK3CA, phosphatidylinositol 3-kinase; KRAS, kristen ras sarcoma viral oncogene
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