HORMONAL BIOMARKERS AND MOLECULAR SUBGROUPS IN EC 141 6 Table 1. Baseline Total N = 739 POLEmut N = 67 (9.1) MMRd N = 204 (27.6) p53mut N = 154 (20.8) NSMP N = 314 (42.5) P Patient characteristics Age (years) 65.0 (31.0-93.0) 57.3 (34.0-93.3) 65.1 (42.0-87.0) 72.6 (35.0-93.0) 62.9 (35.0-88.0) <0.001* BMI (kg/m2) 29.0 (15.8-66.2) 27.6 (18.4-58.3) 29.1 (15.8-62.0) 28.4 (17.5-46.2) 29.6 (15.8-66.2) 0.142 Postoperative histology Histology EEC 594 (80.4) 59 (88.1) 187 (91.7) 57 (37.0) 291 (92.7) <0.001* NEEC 145 (19.6) 8 (11.9) 17 (8.3) 97 (63.0) 23 (7.3) Grade 1-2 394 (53.3) 30 (44.8) 102 (50.0) 22 (14.3) 240 (76.4) <0.001* 3 345 (46.7) 37 (55.2) 102 (50.0) 132 (85.7) 74 (23.6) MIa <50% 400 (54.1) 33 (50.0) 107 (52.5) 75 (50.0) 185 (59.3) 0.172 >50% 332 (44.9) 33 (50.0) 97 (47.5) 75 (50.0) 127 (40.7) LVSI No 474 (64.1) 37 (55.2) 115 (56.4) 78 (50.6) 244 (77.7) <0.001* Yes 265 (35.9) 30 (44.8) 89 (43.6) 76 (49.4) 70 (22.3) Lymph nodes N0 231 (31.3) 31 (46.3) 61 (29.9) 38 (24.7) 101 (32.2) 0.170 N1 54 (7.3) 3 (3.0) 13 (6.4) 15 (9.7) 20 (6.3) Nx 454 (61.4) 34 (50.7) 129 (63.2) 101 (65.6) 190 (39.5) FIGO stagea Early 558 (75.5) 60 (90.9) 154 (75.9) 87 (56.5) 257 (82.6) <0.001* Advanced 176 (23.8) 6 (9.1) 49 (24.1) 67 (43.5) 54 (17.4) Hormonal receptor expression ER 0-10 142 (19.2) 16 (23.9) 39 (19.5) 55 (36.2) 32 (10.2) <0.001* 20-80 354 (47.9) 36 (53.7) 98 (49.0) 74 (48.7) 146 (46.6) 90-100 236 (31.9) 15 (22.4) 63 (31.5) 23 (15.1) 135 (43.1) PR 0-10 241 (32.6) 21 (31.3) 60 (29.7) 101 (66.9) 59 (18.8) <0.001* 20-80 344 (46.5) 39 (58.2) 108 (53.5) 38 (25.2) 159 (50.8) 90-100 148 (20.0) 7 (10.4) 34 (16.8) 12 (7.9) 95 (30.4)
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