CHAPTER 6 146 Table 2. Cox regression univariable and multivariable analysis disease-specific survival (DSS) Variable Univariable Multivariable 141 events HR (95% CI) P value HR (95% CI) P value ER cutoff ER 0-10% 2.16 (1.51-3.08) <0.001 1.20 (0.80-1.79) 0.371 ER 20-80% 1 1 ER 90-100% 0.41 (0.24-0.69) <0.001 0.82 (0.48-1.41) 0.487 PR cutoff PR 0-10% 3.09 (2.19-4.35) <0.001 1.71 (1.11-2.62) 0.014* PR 20-80% 1 1 PR 90-100% 0.34 (0.16-0.71) 0.005 0.41 (0.17-0.95) 0.039* Molecular subgroup POLEmut 0.09 (0.01-0.65) 0.017* 0.06 (0.00-0.50) 0.007* MMRd 1.37 (0.89-2.10) 0.154 0.79 (0.49-1.26) 0.321 p53mut 4.09 (2.81-5.97) <0.001* 1.65 (1.07-2.53) 0.022* NSMP 1 1 LVSI No 1 <0.001* 1 0.003* Yes 4.14 (2.96-5.78) 1.86 (1.23-2.84) FIGO Stage I-II 1 1 <0.001* Stage III-IV 6.17 (4.45-8.55) <0.001* 2.83 (1.89-4.20) Abbreviations: DSS, disease-specific survival; EC, endometrial cancer; HR, hazard ratio; CI, confidence interval; ER, estrogen receptor; PR., progesterone receptor; POLEmut, polymerase epsilon mutant; MMRd, mismatch repair deficient; p53, protein 53; NSMP, No specific molecular profile; LVSI, lympho-vascular space invasion; FIGO, Federation International of Gynecology and Obstetrics. * P<0.05 Outcome ER+PR expression combined Supplementary Figure S2A-E shows the 5-year DSS curve of the three-tiered ER+PR combined risk classification within the entire cohort and the molecular subgroups. The 5-year DSS was significantly different between the three ER+PR risk classification groups (Supplementary Figure S2A). Patients with p53mut EC and ER+PR 90-100% had a 5-year DSS of 100%, and patients with ER+PR 20-80% and 0-10% had comparable outcome as ER+PR 0-10% (respectively, 55.0% and 44.0%). The 5-year DSS between ER+PR 0-10% and 90-100% was significantly different (Supplementary Figure S2D). Within NSMP tumors, patients with ER+PR 90-100% had an excellent 5-year DSS of 98.0%, for ER+PR 20-80% the 5-year DSS was 84.0% and ER+PR 0-10% showed the worst 5-year DSS of 43.0%. All were significantly different from each other (Supplementary Figure S2E). In the entire cohort
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