GENERAL INTRODUCTION 15 1 Immunohistochemical expression ER expression PR expression P53 expression L1CAM expression ER positive PR positive p53 wildtype L1CAM negative A. C. E. H. ER negative PR negative p53 overexpression L1CAM positive B. D. F. I. p53 null-expression G. Figure 2. Immunohistochemical expression of ER, PR, p53 and L1CAM. A/C. Positive ER/PR expression with a cutoff >1 or 10%. B/D. negative ER/PR expression with a cutoff ≤1 or 10%. E. p53wildtype when there is no TP53 mutation. F. p53 overexpression when there is nuclear accumulation of p53 protein caused by a missense mutation of TP53. G. p53 null-expression with a frameshift or nonsense mutation of TP53. H. Negative L1CAM expression with a cutoff <10%. I. Positive L1CAM expression with a cutoff ≥10%. Abbreviations: ER, estrogen receptor; PR, progesterone receptor; p53, protein 53; L1CAM, L1 cell adhesion molecule
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