HORMONAL BIOMARKERS AND MOLECULAR SUBGROUPS IN EC 157 6 Table S2. Cox regression univariable and multivariable analysis disease-specific survival (DSS) Variable Univariable DSS Multivariable DSS 150 events HR (95% CI) P value HR (95% CI) P value ER+PR cutoff ER+PR 0-10% 2.11 (1.43-3.09) <0.001* 1.54 (1.03-2.28) 0.032* ER+PR 20-80% 0.67 (0.44-1.00) 0.052 0.91 (0.59-1.38) 0.656 ER+PR 90-100% 0.21 (0.09-0.47) <0.001* 0.38 (0.17-0.86) 0.020* Discordant 1 1 Molecular subgroup POLEmut 0.09 (0.01-0.65) 0.017* 0.07 (0.00-0.50) 0.008* MMRd 1.37 (0.89-2.10) 0.154 0.94 (0.60-1.46) 0.780 p53mut 4.09 (2.81-5.97) <0.001* 2.02 (1.34-3.06) <0.001* NSMP 1 1 LVSI No 1 <0.001* 1 <0.001* Yes 4.14 (2.96-5.78) 2.11 (1.41-3.15) FIGO Stage I-II 1 1 <0.001* Stage III-IV 6.17 (4.45-8.55) <0.001* 2.95 (2.00-4.33) Abbreviations: DSS, disease-specific survival; EC, endometrial cancer; HR, hazard ratio; CI, confidence interval; POLEmut, polymerase epsilon mutant; MMRd, mismatch repair deficient; p53, protein 53; NSMP, No specific molecular profile; LVSI, lympho-vascular space invasion; FIGO, Federation International of Gynecology and Obstetrics.
RkJQdWJsaXNoZXIy MTk4NDMw