ABNORMAL HAEMATOLOGICAL PARAMETERS IN EC 169 7 Prognostic outcome The 5-year DSS and RFS of preoperative anaemia, thrombocytosis and leucocytosis are shown in Figure 2A-F. Patients with anaemia had a significant reduced 5-year DSS and RFS compared to patients with normal haemoglobin level (respectively, P<0.001 and P<0.001) (Figure 2A, 2D). Patients with thrombocytosis showed significant reduced 5-year DSS compared to normal platelet count (P=0.023), no difference was found for RFS (Figure 2B, 2E). For patients with leucocytosis compared with normal leukocyte count, no significant difference in DSS and RFS was found (Figure 2C, 2F). In multivariable analysis after adjusting for age, the three abnormal haematological parameters and the ESGO/ESTRO/ESP risk groups, only anaemia, age and ESGO/ESTRO/ ESP high- and advanced/metastatic risk groups remained independently associated with a reduced DSS. None of the haematological parameters were independently associated with a decreased RFS (Table 3). Predictive outcome The 5-year DSS and RFS of the preoperative haematological parameters in all patients who received solely adjuvant RT are shown in Figure 3A-F. Anaemia was associated with a significant decreased DSS and RFS compared to normal haemoglobin level (respectively, P=0.005 and P=0.025) (Figure 3A, 3D). Thrombocytosis and leucocytosis did not significantly impact the response to RT (Figure 3B, 3C, 3E, 3F). The 5-year DSS and RFS of the haematological parameters within patients classified as ESGO/ESTRO/ESP intermediate risk who received solely VBT are shown in Figure S2A-E. Patients with anaemia had a significant decreased DSS compared to normal haemoglobin level (P=0.041), this was not significant for the RFS (P=0.214). No significant difference in DSS and RFS were found for patients with thrombocytosis or leucocytosis, however numbers were low.
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