CHAPTER 7 170 Table 3. Cox regression univariable and multivariable analysis of disease-specific survival (DSS) and recurrence-free survival (RFS) Variable Univariable DSS Multivariable DSS Event 66 Univariable RFS Multivariable RFS Event 78 HR (95% CI) P value HR (95% CI) P value HR (95% CI) P value HR (95% CI) P value Patient characteristics Age (continuous) 1.04 (1.02-1.06) <0.001* 1.03 (1.00-1.06) 0.009* 1.04 (1.01-1.05) <0.001* 1.03 (1.00-1.05) 0.022* Haematological parameters Anaemia 3.19 (2.02-5.02) <0.001* 2.31 (1.19-4.50) 0.013* 2.32 (1.49-3.60) <0.001* 1.71 (0.91-3.19) 0.091 Thrombocytosis 1.90 (1.08-3.34) 0.025* 1.06 (0.49-2.30) 0.872 1.31 (0.73-2.36) 0.363 0.70 (0.32-1.55) 0.382 Leucocytosis 1.65 (0.95-2.86) 0.074 1.37 (0.74-2.55) 0.312 1.45 (0.85-2.44) 0.168 1.53 (0.84-2.74) 0.159 ESGO/ESTRO/ESP risk groups Low 1 1 1 1 Intermediate 7.59 (3.01-19.12) <0.001* 3.06 (0.98-9.53) 0.053 6.20 (3.06-12.55) <0.001* 2.38 (0.88-6.39) 0.087 High-intermediate 3.90 (1.38-10.96) 0.010* 1.59 (0.44-5.65) 0.472 5.23 (2.56-10.89) <0.001* 3.43 (1.44-8.16) 0.005* High 32.66 (13.99-76.23) <0.001* 18.3 (7.64-43.94) <0.001* 22.21 (11.64-42.37) <0.001* 16.78 (8.05-34.83) <0.001* Advanced/metastatic 101.97 (40.33-257.79) <0.001* 72.1 (27.36189.97) <0.001* 36.59 (15.79-84.74) <0.001* 33.68 (13.15-86.29) <0.001* Abbreviations: Disease-specific survival (DSS), Recurrence-free survival (RFS), Hazard ratio (HR), Confidence interval (CI), European Society of Gynaecological Oncology (ESGO), European SocieTy for Radiotherapy and Oncology (ESTRO), European Society of Pathology (ESP), * P<0.05
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