CHAPTER 8 186 Table 1. Known association of immune- and molecular markers with pathological and clinical characteristics in endometrial cancer; high, medium, low and unknown association. ER+ ER- PR+ PR- L1CAM+ P53/TP53mut POLEmut MSI/MMRd NSMP Grade 1 EEC High Low High Low Low Low Medium Medium High Grade 2 EEC High Low High Low Low Medium Medium Medium High Grade 3 EEC Low Medium Low Medium High High High Medium Low NEEC Low High Low High High High Low Low Low LVSI Low High Low High High High Unknown Unknown Unknown MI >50% Low Medium Low High High High Unknown Unknown Unknown CA 125 >35 kU/l Unknown Unknown Unknown Unknown High High Unknown Unknown Unknown LNM Low High Low High High High Unknown Unknown Unknown Abbreviations: EEC, endometrioid endometrial cancer; NEEC, non-endometrioid endometrial cancer; LVSI, lympho-vascular space invasion; MI, myometrial invasion; CA 125, cancer antigen 125; LNM, lymph node metastasis; ER, estrogen receptor; PR, progesterone receptor; L1CAM, L1 cell adhesion molecule, TP53mut, tumor protein 53 mutant, POLEmut, polymerase epsilon mutant; MSI, microsatellite instable; MMRd, mismatch repair deficient; NSMP, no specific molecular profile.
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