GENERAL DISCUSSION 191 8 Figure 1. A. Revised ENDORISK-model for optimalisation of primary treatment. Circled in purple, the variables that will be added to the current ENDORISK-model. B. Current ENDORISK-model user interface for doctors, available at www.endorisk.eu Abbreviations: L1CAM, L1 cell adhesion molecule; TP53, tumor protein 53; POLE, polymerase epsilon; MS, microsatellite; MMR, mismatch repair; TVU, transvaginal ultrasound; MRI, magnetic resonance imaging; LNM, lymph node metastasis; CA125, cancer antigen; BMI, Body mass index Proposed clinical decision tool for primary treatment of endometrial cancer A clinical decision tool including a diagnostic algorithm for EC is proposed, retaining histomorphology and optimizing the use of clinical, IHC and/or molecular markers, to improve prognostication thereby limiting health-care costs. Figure 2 shows a proposed clinical decision tool for the primary treatment of EC. Grade 1 EC has an overall good prognosis, so extra diagnostics in these patients are not necessary.
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