CHAPTER 2 32 In Supplementary Table S1 detailed baseline information about patients diagnosed with postoperative NEEC (n=34) is shown. Most patients with NEEC had serous histology (n=14, 41.2%). Concordance pre- and postoperative tumor grade and histology Figure 1 shows the number and percentages of the pre- vs. postoperative individual tumor grade and histological subtype. Dark green shows the exact concordance between grading and histology, light green the concordance for the clinically relevant low- and high-grade classification and in red the clinically relevant discordancy. Overall, of the 573 EC tissue samples, 60.0% (n=345) showed concordant pre- and postoperative tumor grade and histological subtype (dark green). The lowest concordance was found for preoperative grade 3 EC (51.4%). Concordance between pre-and postoperative low- and high-grade EC was found in 88.8% (n=509) patients (light green + dark green). Patients with preoperative low-grade EC showed concordant diagnoses in 92.2% (n=435) and were upgraded to high-grade EC in 7.8% (n=37). Patients with preoperative high-grade EC showed concordant diagnoses in 73.3% (n=74) and were downgraded in 26.7% (n=27). Grade1 2 (7.4) Grade1 5 (6.8) Grade1 33 (21.2) Grade1 192 (62.3) Grade1 5 (62.5) Grade2 3 (11.1) Grade2 17 (23.0) Grade2 99 (63.5) Grade2 103 (33.4) Grade2 3 (37.5) Grade3 6 (22.2) Grade3 38 (51.4) Grade3 20 (12.8) Grade3 13 (4.3) NEEC 0 (0.0) NEEC 16 (59.3) NEEC 14 (18.8) NEEC 4 (2.5) NEEC 0 (0.0) Grade 3 0 (0.0) 0 20 40 60 80 100 NEEC Grade 3 EEC Grade 2 EEC Grade 1 EEC Premalignant Postoperative Preoperative Percentage Figure 1. Number and percentages (n (%)) of the pre- vs. postoperative individual tumor grade and histological subtype. Abbreviations: EEC, endometroid endometrial cancer; NEEC, non-endometroid endometrial cancer
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