AMOUNT OF PREOPERATIVE ENDOMETRIAL TISSUE 47 2 Table S3. Patient characteristics versus the preoperative sampling method. Total (n=549)†† Pipelle (n=259) D&C (n=77) Hysteroscopic biopsy (n=213) P Preoperative Premalignant† 8 (1.5) 8 (100.0) NA NA <0.001* Grade 1 EEC 302 (55.0) 118 (45.6) 42 (54.5) 142 (66.7) Grade 2 EEC 150 (27.3) 79 (30.5) 18 (23.4) 53 (24.9) Grade 3 EEC 67 (12.2) 41 (15.8) 15 (19.5) 11 (5.2) NEEC 22 (4.0) 13 (5.0) 2 (2.6) 7 (3.3) Postoperative Grade 1 EEC 230 (41.9) 94 (36.3) 40 (51.9) 96 (45.1) 0.002* Grade 2 EEC 221 (40.3) 105 (40.5) 23 (29.9) 93 (43.7) Grade 3 EEC 71 (12.9) 39 (15.1) 11 (14.3) 21 (9.9) NEEC 27 (4.9) 21 (8.1) 3 (3.9) 3 (1.4) Concordant low- and high-grade EC 488 (88.9) 225 (86.9) 70 (90.9) 20 (90.6) 0.364 Concordant tumor grade and histology subtype 335 (61.0) 168 (64.9) 49 (63.6) 118 (55.4) 0.097 Downgraded (preoperative high- and postoperative low-grade) 26 (4.7) 14 (5.4) 5 (6.5) 7 (3.3) 0.237 Upgraded (preoperative low- and postoperative high-grade) 35 (6.4) 20 (7.7) 2 (2.6) 13 (6.1) Data is presented in number (%) Abbreviations: EC, endometrial cancer; EEC, endometroid endometrial cancer; NEEC, non-endometroid endometrial cancer; D&C, dilatation & curettage. *p<0.05, †including simple or complex hyperplasia, with or without atypia, †† n=24 missing sampling method
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