CHAPTER 3 60 Table 2. Cox regression univariable and multivariable analysis disease-specific survival (DSS) of the entire cohort and within low-grade EC Variable Entire cohort Univariable DSS Entire cohort Multivariable DSS 73 events Low-grade EC Univariable DSS Low-grade EC Multivariable DSS 12 events HR (95% CI) P value HR (95% CI) P value HR (95% CI) P value HR (95% CI) P value Patient characteristics Age (continuous) 1.04 (1.02-1.07) .001 1.02 (0.99-1.05) .08 a a Grade 1-2 1 <.001 1 <.001 a a 3 7.70 (4.13-14.35) 4.29 (2.15-8.53) Molecular subgroup POLE-mutant 0.17 (0.02-1.27) .09 0.16 (0.02-1.16) .07 0.00 (0.00-0.00) .99 0.00 (0.00-0.00) .98 MSI 0.45 (0.19-1.11) .08 0.51 (0.21-1.22) .13 0.73 (0.15-3.40) .69 0.65 (0.13-3.02) .58 TP53-mutant 4.14 (2.53-6.75) <.001 1.76 (1.04-2.95) .03 1.58 (0.19-12.63) .66 2.94 (0.33-25.83) .63 NSMP 1 1 1 1 LVSI No 1 <.001 1 .64 1 .30 1 .78 Yes 3.78 (2.37-6.00) 1.13 (0.67-1.88) 2.27 (0.48-10.57) 1.28 (0.24-6.88) FIGO Stage I-II 1 <.001 1 <.001 1 .01 1 .008 Stage III-IV 7.02 (4.35-11.33) 4.26 (2.50-7.26) 4.57 (1.43-14.56) 5.38 (1.55-18.62) Abbreviations: DSS, disease-specific survival; EC, endometrial cancer; HR, hazard ratio; CI, confidence interval; POLE, Polymerase epsilon; MSI, Microsatellite instability; TP53, Tumor protein; NSMP, No-specific molecular profile, LVSI, lymphovascular space invasion; FIGO, Federation International of Gynecology and Obstetrics. aCox-regression analysis within low-grade EC patients did not included age and grade as variables.
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