MOLECULAR PROFILING IN LOW-GRADE EC 73 3 eTable 3. Cox regression univariable and multivariable analysis of disease-specific survival (DSS) in high-grade EC patients Variable Univariable DSS Multivariable DSS 61 events HR (95% CI) P value HR (95% CI) P value Molecular subgroup POLE-mutant 0.15 (0.02-1.09) .06 0.19 (0.02-1.46) .12 MSI 0.27 (0.09-0.77) .02 0.45 (0.16-1.24) .12 TP53-mutant 1.93 (1.13-3.28) .02 1.70 (0.99-2.91) .05 NSMP 1 1 LVSI No 1 .002 1 .67 Yes 2.23 (1.34-3.68) 1.12 (0.65-1.92) FIGO Stage I-II 1 <.001 1 <.001 Stage III-IV 5.67 (3.30-9.73) 4.05 (2.24-7.29) Abbreviations: DSS, disease-specific survival; HR, hazard ratio; CI, confidence interval; POLE, Polymerase epsilon; MSI, Microsatellite instability; TP53, Tumor protein; NSMP, No-specific molecular profile, LVSI, lymphovascular space invasion; FIGO, Federation International of Gynecology and Obstetrics.
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