PURE AND MIXED CLEAR CELL CARCINOMA 83 4 RESULTS Patients A total of 72 patients were identified of which 29 were excluded (n=8 after pathology review, n=13 due to insufficient tissue, n=2 because of missing follow-up and n=6 due to palliative treatment). A total of 43 patients were included in the analysis, of which 22 (51%) were pure uterine CCC and 21 (49%) mixed uterine CCC. Median age was 70 years (range 48 – 88) and did not differ between patients with pure or mixed uterine CCC (Table 1). The second histological component in mixed uterine CCC consisted of endometrioid histology in 16 patients (76%), serous histology in 3 patients (14%) and endometrioid + serous histology in 2 patients (10%). In patients with pure uterine CCC, 12 patients (55%) presented with FIGO stage III-IV disease, compared to 6 patients (29%, p = 0.084) with mixed uterine CCC. As shown in Table 2, ER an PR IHC stains were reflective of the mixed components as the clear cell component was mostly negative for ER and PR and the other histological components were mostly positive. The use of adjuvant therapy did not differ significantly between groups. In patients with pure uterine CCC, 11 patients (50%) died in the follow-up period, compared to 4 patients (19%, p = 0.033) with mixed uterine CCC.
RkJQdWJsaXNoZXIy MTk4NDMw