PURE AND MIXED CLEAR CELL CARCINOMA 87 4 Table 3. Molecular patterns of pure and mixed clear cell carcinomas Pure CC Mixed P AKT Wildtype Mutated 16 (94) 1 (6) 17 (94) 1 (6) 1.000 ARID1A Wildtype Mutated 10 (59) 7 (41) 7 (39) 11 (61) 0.318 CTNNB1 Wildtype Mutated 16 (94) 1 (6) 17 (94) 1 (6) 1.000 ERBB2 Wildtype Mutated 15 (88) 2 (12) 16 (89) 2 (11) 1.000 KRAS Wildtype Mutated 17 (100) 0 16 (89) 2 (11) 0.486 MTOR Wildtype Mutated 17 (100) 0 15 (83) 3 (17) 0.229 NRAS Wildtype Mutated 16 (94) 1 (6) 17 (94) 1 (6) 1.000 PIK3CA Wildtype Mutated 13 (77) 4 (24) 10 (56) 8 (44) 0.289 POLE Wildtype Mutated 17 (100) 0 17 (94) 1 (6) 1.000 PTEN Wildtype Mutated 14 (82) 3 (18) 9 (50) 9 (50) 0.075 TP53 Wildtype Mutated 10 (59) 7 (41) 11 (61) 7 (39) 1.000 MSI No Yes 21 (96) 1 (5) 12 (57) 9 (43) 0.004 Molecular subgroup POLE mutated MSI TP53 wildtype TP53 mutated 0 1 (6) 10 (56) 7 (39) 1 (6) 9 (50) 4 (22) 4 (22) 0.013
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