PURE AND MIXED CLEAR CELL CARCINOMA 89 4 40 60 80 Overall survival (months) A. 120 100 20 0 Survival 1,0 0,8 0,6 0,4 0,2 0,0 Histology Pure Mixed Pure-censored Mixed-censored B. 40 60 80 Overall survival (months) 120 100 20 0 Survival 1,0 0,8 0,6 0,4 0,2 0,0 POLE mutated-censored MSI-censored TP53 wildtype-censored TP53 mutated-censored Molecular subgroup POLE mutated MSI TP53 wildtype TP53 mutated 1,0 L1CAM expression p=0.029 p=0.003 40 60 80 Overall survival (months) A. 120 100 20 0 Survival 1,0 0,8 0,6 0,4 0,2 0,0 Histology Pure Mixed Pure-censored Mixed-censored B. 40 60 80 Overall survival (months) 120 100 20 0 Survival 1,0 0,8 0,6 0,4 0,2 0,0 POLE mutated-censored MSI-censored TP53 wildtype-censored TP53 mutated-censored Molecular subgroup POLE mutated MSI TP53 wildtype TP53 mutated val 1,0 0,8 0,6 L1CAM expression Positive Negative Positive-censored Negative-censore p=0.029 p=0.003
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