CHAPTER 4 90 40 60 80 Overall survival (months) C. 120 100 20 0 Survival 1,0 0,8 0,6 0,4 0,2 0,0 L1CAM expression Positive Negative Positive-censored Negative-censore p=0.035 Figure 2. Kaplan Meier curves displaying overall survival according to histology (A), molecular subgroup (B), and L1CAM-expression (C) Table 4A. Overall survival (OS) by histology in univariable and multivariable Cox regression analysis. Univariable Multivariable HR 95% CI P HR 95% CI P Histology Pure Mixed 0.30 (0.10 – 0.94) 0.04 0.69 (0.15 – 3.18) 0.64 Age 1.02 (0.96 – 1.08) 0.60 - FIGO I/II III/IV 5.3 (1.66 – 16.8) 0.01 2.39 (0.62 – 9.19) 0.21 TCGA TP53 wildtype POLE mutated MSI TP53 mutated No events 0.37 (0.04 – 3.55) 4.69 (1.24 – 17.8) - 0.39 0.02 No events 0.61 (0.05 – 6.79) 3.94 (1.00 – 15.6) - 0.69 0.05 Abbreviations: DSS, disease-specific survival; EC, endometrial cancer; HR, hazard ratio; CI, confidence interval; POLE, Polymerase epsilon; MSI, Microsatellite instability; TP53, Tumor protein; NSMP, No-specific molecular profile, LVSI, lymphovascular space invasion; FIGO, Federation International of Gynecology and Obstetrics.
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