PURE AND MIXED CLEAR CELL CARCINOMA 99 4 Supplementary C. Sequencing results Study number Variant Variant allele frequency N of mutant reads Variant class 1EEC ARID1A:c.2178-2187del p.(Arg727fs) 70 468 4 1CC ARID1A:c.2178-2187del p.(Arg727fs) 52 64 4 1CC PIK3CA:c.3140A>G p.(His1047Arg) 52 182 5 1CC PTEN:c.113del p.(Pro38fs) 33 68 4 1 Microsatellite stable 2 TP53:c.396G>C p.(Lys132Asn) 49 46 4 2 Microsatellite stable 3EEC ARID1A:c.1181del p.(Pro394fs) 47 14 4 3CC PTEN:c.428del p.(Gly143fs) 62 26 4 3 Microsatellite stable 4 No (potentially) pathogenic variants Microsatellite stable 5 No (potentially) pathogenic variants Microsatellite stable 6 AKT1:c.49G>A p.(Glu17Lys) 73 462 5 6 ARID1A:c.6301_6302dup p.(Asp210fs) 28 38 4 6 CTNNB1:c.94G>T p.(Asp32Tyr) 21 108 5 6 TP53:c.658T>G p.(Tyr220Asp) 70 142 4 6 Microsatellite stable 8 PTEN:c.697C>T p.(Arg233*) 58 1096 4 8 Microsatellite stable 10 ARIDA1:c.1353_1354del p.(Pro452fs) 34 104 4 10 Microsatellite stable 11 No (potentially) pathogenic variants Microsatellite stable 13EEC PTEN:c.723dup p.(Glu242*) 30 92 4 13CC PTEN:c.723dup p.(Glu242*) 30 92 4 13CC ARID1A:c.5548del p.(Asp1850fs) 29 28 4 13CC NRAS:c.3G>A p.(Thr2_Met67del) 31 214 5 13CC PIK3CA:c.3140A>G p.(His1047Arg) 30 182 5 13 Microsatellite instable 15 PTEN:c.405dup p.(Cys136fs) 50 134 4
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