18 Chapter 1 (Figure 4). This data will define a subset of chemical probes for interrogating cardiomyocyte phenotyping and provide validation of a platform for high-throughput screening of hiPSC- derived cardiomyocytes. Figure 4. Graphical abstract of patient-derived human cardiomyocyte models for therapeutic screenings and disease modeling in vitro. THESIS OUTLINE The aim of this thesis is to shed light on the utilization of functional patient-derived humaninduced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) for disease modeling and high throughput screening of novel therapeutic strategies for genetic cardiomyopathies. This goal is achieved in two ways: firstly, by investigating the developmental clues of cardiogenesis for the generation of hiPSC-CMs, and secondly, by showing that the patient hiPSC-CMs can be conducted with scientifically sound methods using pragmatic in vitro disease models and innovative disease pathway analysis.
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