Renée Maas

226 Chapter 8 17. Opbergen CJM van, Braven L den, Delmar M, Veen TAB van. Mitochondrial Dysfunction as Substrate for Arrhythmogenic Cardiomyopathy: A Search for New Disease Mechanisms. Front Physiol 2019;0. 18. Haghighi K, Gardner G, Vafiadaki E, Kumar M, Green LC, Ma J, Crocker JS, Koch S, Arvanitis DA, Bidwell P, Rubinstein J, Leur R van de, Doevendans PA, Akar FG, Tranter M, Wang H-S, Sadayappan S, DeMazumder D, Sanoudou D, Hajjar RJ, Stillitano F, Kranias EG. Impaired Right Ventricular Calcium Cycling Is an Early Risk Factor in R14del-Phospholamban Arrhythmias. Journal of Personalized Medicine 2021;11. 19. Shah K, Wei C-Y, Kim C-S, Wong J, Wen J-Y, Tirasawasdichai T, Wang C, -S. Vincent Chen H. Modeling Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy with Patient-Specific iPSCs. Human iPS Cells in Disease Modelling. Springer, Tokyo; 2016. p27–43. 20. Haemmerle G, Moustafa T, Woelkart G, Büttner S, Schmidt A, Weijer T van de, Hesselink M, Jaeger D, Kienesberger PC, Zierler K, Schreiber R, Eichmann T, Kolb D, Kotzbeck P, Schweiger M, Kumari M, Eder S, Schoiswohl G, Wongsiriroj N, Pollak NM, Radner FPW, Preiss-Landl K, Kolbe T, Rülicke T, Pieske B, Trauner M, Lass A, Zimmermann R, Hoefler G, Cinti S, Kershaw EE, Schrauwen P, Madeo F, Mayer B, Zechner R. ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-α and PGC-1. Nat Med 17:1076. 21. Lawrence Merritt J, II, Norris M, Kanungo S. Fatty acid oxidation disorders. Annals of Translational Medicine 2018;6. 22. Goldberg IJ, Trent CM, Christian Schulze P. Lipid Metabolism and Toxicity in the Heart. Cell Metab 2012;15:805. 23. Christian Schulze P, Drosatos K, Goldberg IJ. Lipid Use and Misuse by the Heart. Circ Res 2016;118:1736. 24. Osorio JC, Stanley WC, Linke A, Castellari M, Diep QN, Panchal AR, Hintze TH, Lopaschuk GD, Recchia FA. Impaired Myocardial Fatty Acid Oxidation and Reduced Protein Expression of Retinoid X Receptor-α in PacingInduced Heart Failure. Circulation. 25. Carvajal K, Moreno-Sánchez R. Heart Metabolic Disturbances in Cardiovascular Diseases. Archives of Medical Research. 26. Kolwicz SC Jr, Purohit S, Tian R. Cardiac metabolism and its interactions with contraction, growth, and survival of cardiomyocytes. Circ Res 2013;113:603–616. 27. Dávila-Román VG, Vedala G, Herrero P, Fuentes L de las, Rogers JG, Kelly DP, Gropler RJ. Altered myocardial fatty acid and glucose metabolism in idiopathic dilated cardiomyopathy. J Am Coll Cardiol 2002;40:271–277. 28. Pei J, Harakalova M, Treibel TA, Lumbers RT, Boukens BJ, Efimov IR, Dinter JT van, González A, López B, El Azzouzi H, Dungen N van den, Dijk CGM van, Krebber MM, Ruijter HM den, Pasterkamp G, Duncker DJ, Nieuwenhuis EES, Weger R de, Huibers MM, Vink A, Moore JH, Moon JC, Verhaar MC, Kararigas G, Mokry M, Asselbergs FW, Cheng C. H3K27ac acetylome signatures reveal the epigenomic reorganization in remodeled non-failing human hearts. Clin Epigenetics 2020;12:1–18. 29. Pei J, Schuldt M, Nagyova E, Gu Z, Bouhaddani S el, Yiangou L, Jansen M, Calis JJA, Dorsch LM, Blok CS, Dungen NAM van den, Lansu N, Boukens BJ, Efimov IR, Michels M, Verhaar MC, Weger R de, Vink A, Steenbeek FG van, Baas AF, Davis RP, Uh HW, Kuster DWD, Cheng C, Mokry M, Velden J van der, Asselbergs FW, Harakalova M. Multiomics integration identifies key upstream regulators of pathomechanisms in hypertrophic cardiomyopathy due to truncating MYBPC3 mutations. Clin Epigenetics 2021;13:1–20. 30. Feyen DAM, McKeithan WL, Bruyneel AAN, Spiering S, Hörmann L, Ulmer B, Zhang H, Briganti F, Schweizer M, Hegyi B, Liao Z, Pölönen RP, Ginsburg KS, Lam CK, Serrano R, Wahlquist C, Kreymerman A, Vu M, Amatya PL, Behrens CS, Ranjbarvaziri S, Maas RGC, Greenhaw M, Bernstein D, Wu JC, Bers DM, Eschenhagen T, Metallo CM, Mercola M. Metabolic Maturation Media Improve Physiological Function of Human iPSC-Derived Cardiomyocytes. Cell Rep 2020;32. 31. Feyen DAM, Perea-Gil I, Maas RGC, Harakalova M, Gavidia AA, Arthur AJ, Wu TH, Vink A, Pei J, Vadgama N, Suurmeijer AJ, Te Rijdt WP, Vu M, Amatya PL, Prado M, Zhang Y, Dunkenberger L, Sluijter JPG, Sallam K, Asselbergs FW, Mercola M, Karakikes I. Unfolded Protein Response as a Compensatory Mechanism and Potential Therapeutic Target in PLN R14del Cardiomyopathy. Circulation 2021;144. 32. Finck BN. The PPAR regulatory system in cardiac physiology and disease. Cardiovasc Res 2007;73:269–277. 33. Grygiel-Górniak B. Peroxisome proliferator-activated receptors and their ligands: nutritional and clinical implications - a review. Nutr J 2014;13:1–10.

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