233 Fatty Acid Oxidation in PLN R14del Cardiomyopathy 8 Supplementary Figure 3 can be downloaded from: https://assets.researchsquare.com/files/ rs-1902254/v1/977dcee472f47c215db074e3.png Supplementary Figure 3: A) Selected examples of protein-protein-interaction networks using annotated transcription factors (TFs) that were predicted to binding to motifs enriched in differentially acetylated regions. B) Selected examples of TFs with both differentially acetylated promoter as well as their corresponding motifs enriched in differentially acetylated regions. Dot plots represent the acetylation signal (AcS) measured for each sample. Supplementary Figure 4 can be downloaded from: https://assets.researchsquare.com/files/ rs-1902254/v1/7e4d95a33e96fef1d7530156.png Supplementary Figure 4: PLN-specificity analysis of differentially acetylated regions (ChIPseq): K-mean clustering of PLN R14del cardiomyopathy (red), healthy controls (green), ischemic cardiomyopathy (dark blue) and sarcomeric non-ischemic cardiomyopathy (light blue) based on H3K27ac signal was used to partition the regions into 12 different clusters. A) K-mean clusters showing PLN-specific hyper- and hypoacetylation regions when compared with controls and hearts with ischemic or non-ischemic dilated cardiomyopathy in general; B) Examples of 8 PLN-specific regions and genes in the vicinity of these regions (LINC01140, WIPF1, OSR1, IFFO2, LTBP1,GCGR, or CNNM4). No genes have been annotated in the vicinity of region 1689.
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