334 Chapter 12 Supplementary Table 2: Differentially expressed genes in CMs from PLN-R14del and CTL spheroids. Gene Abbreviation Function P Value FDR Phenotype Class Polyubiquitin-C UBC Increases ubiquitin necessary to remove unfolded proteins 1.02E21 1.06E17 Unfolded Protein Response Golgin subfamily A member 1 GOLGA1 Participates in glycosylation and transport of proteins/lipids 4.94E20 2.55E16 N/A RNA, U4 Small Nuclear 2 RNU4-2 Affiliated with the snRNA class 1.87E17 6.46E14 N/A Transmembrane Protein 71 TMEM71 Mitochondrial membrane protein involved in immune and inflammatory response, cell proliferation and cell migration 4.09E14 1.06E10 Mitochondrial function Long Intergenic NonProtein Coding RNA 1099 LINC01099 Affiliated with the lncRNA class 7.64E14 1.58E10 N/A AC092957.1 AC092957.1 N/A 2.99E13 5.16E10 N/A AFG3 Like Matrix AAA Peptidase Subunit 1, Pseudogene AFG3L1P Mitochondrial protein processing 2.14E12 3.16E09 Mitochondrial function Heat Shock Protein 90 Beta Family Member 1 HSP90B1 Chaperone functions in folding stabilization 6.96E12 8.99E09 Unfolded Protein Response Sphingosine Kinase Type 1-Interacting Protein SPHKAP Protein kinase A binding activity in Z disc 7.74E11 8.88E08 Contractility Copine 5 CPNE5 Calcium-dependent membrane-binding protein 6.93E10 7.17E07 Calcium Handling Integrin Subunit Beta 3 ITGB3 Cell adhesion as well as cell-surface mediated signalling 7.72E10 7.25E07 Fibrosis Transmembrane Protein 132D TMEM132D Methylation during stress 8.87E10 7.64E07 Unfolded Protein Response Isoprenylcysteine Carboxyl Methyltransferase ICMT Modifies isoprenylated C-terminal cysteine residues of proteins in ER 9.97E10 7.93E07 N/A Thioredoxin Interacting Protein TXNIP Major regulator of cellular redox signaling which protects cells from oxidative stress 1.18E09 8.68E07 Unfolded Protein Response Mitochondrially Encoded Cytochrome C Oxidase III MT-CO3 Enable electron transfer activity and oxidoreduction-driven active transmembrane transporter activity in mitochondria 1.77E09 1.22E06 Mitochondrial function SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily D, Member 3 SMARCD3 Member of the SWI/SNF family of proteins, display helicase and ATPase activities and regulates transcription of certain genes by altering the chromatin structure around those genes. 2.29E09 1.48E06 N/A Arginine And Glutamate Rich 1 ARGLU1 Enables cadherin binding activity 4.79E09 2.91E06 N/A
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