336 Chapter 12 Supplementary Table 3: Differential expressed gene modules in CMs from PLN-R14del and CTL spheroids. Module name Up /down Description of module P-value FDR Phenotype Class REACTOME_NETRIN_1_SIGNALING Up Netrin-1 signaling 0.0002 0.17976 N/A REACTOME_GLI_PROTEINS_BIND_ PROMOTERS_OF_HH_RESPONSIVE_GENES_ TO_PROMOTE_TRANSCRIPTION Up GLI proteins bind promoters of Hh responsive genes to promote transcription 0.0002 0.17976 N/A HALLMARK_MYOGENESIS Down Development of skeletal muscle (myogenesis) 0.0008 0.34865 Contractility REACTOME_NETRIN_MEDIATED_ REPULSION_SIGNALS Up Netrin mediated repulsion signals 0.0010 0.34865 N/A REACTOME_LAMININ_INTERACTIONS Down Laminin interactions 0.0011 0.34865 Fibrosis KEGG_ANTIGEN_PROCESSING_AND_ PRESENTATION Up Antigen processing and presentation 0.0012 0.34865 N/A REACTOME_STRIATED_MUSCLE_ CONTRACTION Down Striated Muscle Contraction 0.0015 0.38054 Contractility REACTOME_SCAVENGING_BY_CLASS_F_ RECEPTORS Up Scavenging by Class F Receptors 0.0020 0.38876 N/A REACTOME_IMMUNOREGULATORY_ INTERACTIONS_BETWEEN_A_LYMPHOID_ AND_A_NON_LYMPHOID_CELL Up Immunoregulatory interactions between Lymphoid - non-Lymphoid 0.0020 0.38876 N/A REACTOME_IRAK1_RECRUITS_IKK_COMPLEX Up DIRAK1 recruits IKK complex 0.0026 0.45041 N/A REACTOME_LIGAND_RECEPTOR_ INTERACTIONS Up Ligand-receptor interactions 0.0034 0.50318 N/A KEGG_HYPERTROPHIC_CARDIOMYOPATHY_ HCM Down Hypertrophic cardiomyopathy (HCM) 0.0036 0.50318 Contractility REACTOME_DSCAM_INTERACTIONS Up DSCAM interactions 0.0042 0.50318 N/A REACTOME_RRNA_PROCESSING Up rRNA processing 0.0042 0.50318 N/A REACTOME_REGULATION_OF_ COMMISSURAL_AXON_PATHFINDING_BY_ SLIT_AND_ROBO Up Regulation of commissural axon pathfinding by SLIT and ROBO 0.0044 0.50318 N/A REACTOME_TRIGLYCERIDE_CATABOLISM Down Triglyceride catabolism 0.0051 0.50318 Mitochondrial function REACTOME_NONSENSE_MEDIATED_DECAY_ NMD Up Nonsense-Mediated Decay (NMD) 0.0060 0.50318 N/A REACTOME_RAB_GEFS_EXCHANGE_GTP_ FOR_GDP_ON_RABS Down RAB GEFs exchange GTP for GDP on RABs 0.0060 0.50318 N/A REACTOME_CHOLESTEROL_BIOSYNTHESIS Up Cholesterol biosynthesis 0.0063 0.50318 Mitochondrial function REACTOME_AGGREPHAGY Up Aggrephagy 0.0064 0.50318 Unfolded Protein Response
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