340 Chapter 12 Supplementary Figure 4 Supplementary Figure 4. Size measurements of hCSs with various ratios of hiPSC-CMs + hiPSC-CFs from wild type (CTR lines) and PLN-R14del patients (R14del lines). (A) Quantification of spheroid size in the isogenic control line (C31iCTRL) with 100% hiPSC-CFs (left), the various ratios (middle), and 100% hiPSC-CMs (right) during culturing (Day 2, 7, 14, and 21). (B) Quantification of spheroid size in the PLNR14del line (D4iR14del). * P< 0.05 - **** P < 0.0001 vs. hiPSC-CF hCSs group analyzed by 1-way ANOVA. Each dot represents one individual spheroid and 2 biological replicates per condition were included in this analysis. (C) Overtime quantification of the isogenic control (C31iCTR) line spheroid size. (D) Overtime quantification of the D4iR14del line spheroid size as displayed in A.
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