343 Modeling and Rescue of PLN-R14del Cardiomyopathy Phenotype in Human iPSC-Derived Cardiac Spheroids 12 Supplementary Figure 7 Supplementary Figure 7. hCS gene expression after AAV.I-1c treatment. (A) qPCR analysis of various genes involved in fibroblast activation (A), hypertrophy (B), Ca2+ handling (C), Thin myofilaments (D), and PLN and SERCA (E) expression in controls, PLN-R14del hCSs, and the treatment with AAV.I-1c. **** P < 0.0001 vs. each group by 2-way ANOVA. Each dot represents one individual spheroid and 2-3 biological replicates per condition were included in this analysis.
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